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They also suppress appetite as well as regulate energy homeostasis by stimulating the secretion of hormones such as GLP-1 from intestinal L cells (De Silva and Bloom, 2012)

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Dose Titration, Tolerance, and Individual Response Timelines Tirzepatide typically begins at 2.5 mg weekly and increases every four weeks (2.5 → 5 → 7.5 → 10 → 12.5 → 15 mg) based on tolerance and response